A series of polymers with different monomer ratios were synthesized by using methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (HEMA), stearyl methacrylates (SMA), 3-(acryloyloxy)propyltrimethoxysilane (AC-76) and 2-(perfluorooctyl)ethyl methacrylate (FOEMA) and used to construct weather resistant self-cleaning coatings. The molecular structure of the polymers were characterized by FTIR and 1H NMR. The effect of mass fraction of FOEMA and SMA on the transmittance and hydrophobicity of the coating was studied by a spectrophotometer and a contact angle meter. When the mass fraction of SMA was 10% and the mass fraction of FOEMA was 15% (based on the total mass of the reaction system, the same below), the prepared coating P3 had the maximum transmittance and water contact angle, which were 98.6% and 105.3°, respectively. The results of artificial accelerated aging experiments show that the coating P3 has excellent weather resistance. After 5000 h of accelerated aging, the gloss retention and hydrophobicity of the coating changed little. The results of the drop slip and graffiti experiments show that the coating P3 has excellent antifouling and self-cleaning effects. The friction test results show that the contact angle of the coating P3 is still greater than 95° after 100 times of friction under 900 g pressure, indicating that it has excellent mechanical stability. Finally, the coating was sprayed on the high-speed railway carriage, which has a significant self-cleaning effect on the actual pollutants on the exterior body of the carriage.