Amino acid metal-organic framework is a kind of material with periodic structure, which is synthesized with the participation of metal ions and amino acids as organic ligands. As a component of protein, amino acids have the advantages of the green environmental protection, good biocompatibility, variety and low price. Introducing them into MOF can endow materials with special flexible structure, rich active sites, special structure and other characteristics, which has aroused great interest of researchers. The review first elaborates the structure-dimensional classification of amino acid MOFs. Secondly, the main synthesis methods of amino acid MOF include solvothermal method, mechanochemical synthesis method, microwave heating auxiliary method. The performance regulation of materials is then further explained. On this basis, the applications of these materials in chiral separation, catalysis, adsorption and other fields are introduced emphatically. Finally, by analyzing the problems of poor material stability, unpredictable structure, the future research of amino acid metal-organic framework materials is prospected.