Bisphenol A based polycarbonate (BPA-PC) by petroleum as raw materials is limited in the application of food packaging and other fields due to the non-renewable and estrogenic effects of bisphenol A. In recent years, Isosorbide (IS), as a bio-based renewable monomer that is non-toxic and harmless, is currently the most promising key raw material for replacing bisphenol A in the synthesis of polycarbonates. And the isosorbide based polycarbonate (IS-PC) has non-toxicity, excellent optical properties, scratch resistance, thermal stability, biodegradability and biocompatibility, which has shown good application prospects in packaging, automobiles, electronics, biomedicine and other fields. This article reviews the preparation methods and performance regulation of IS-PC, focusing on the preparation of IS-PC by melt transesterificationthe, summarizing the methods of regulating the performance of isosorbide polycarbonate ( IS-PC ) and prospects for the research direction of IS-PC.