Weather-resistance plasticizers of hexa-hydro-phthalic ethylene glycol ether esters (HHPE) were synthesized using hexa-hydro-phthalic anhydride and ethylene glycol ether (ethylene/diethylene /triethylene/tetraethylene glycol glycol methyl ether, ethylene/diethylene/triethylene glycol butyl ether) as feedstocks via direct esterification. The structures of resulting products were confirmed by _¹H NMR and FT-IR, respectively. In addition, performances of mechanical, microstructure, thermal stability, migration resistance the volatilization resistance, as well as weather resistance of PVC plasticized by HHPE were systematically investigated. The results indicated that the plasticization of HHPE increased along with the increase of the number of ethoxy group when the ethoxy units in the structure were less than 4. Compared with the PVC sample plasticized by dioctyl phthalate (DOP), the elongation at break and the initial thermal decomposition temperature (T_5%) of the products plasticized by hexa-hydro-phthalic anhydride di (triethylene glycol methyl ether) ester (HHPTEM) respectively increased by 88% and 20.2 ℃, while the migration in n-hexane and toluene, as well as the volatility at 70 ℃ of HHPTEM/PVC decreased by 7.6%, 4.9% and 1.9%, respectively. Additionally, the retention rate of elongation at break increased by 8.6% after 10 days of UV aging.