Three kinds of TiO2 supports (TiO2-G, TiO2-E and TiO2-H) were synthesized by using tetrabutyl titanate as raw material through hydrothermal method, and the active components Au and Pd were loaded onto the support by using sol-immobilization method to obtain three different AuPd/TiO2 catalysts, which were used for benzyl alcohol catalytic oxidation under solvent-free. By combining the characterizations of XRD, XPS, N2-BET, EPR and TEM, the influence of different oxygen vacancy contents in TiO2 carrier on the catalytic performance of AuPd/TiO2 in benzyl alcohol oxidation was investigated under solvent-free.The experimental results showed that the AuPd/TiO2-G with the highest oxygen vacancy content (0.198) and the smallest sized AuPd nanoparticles (1.83 nm) performed the best benzyl alcohol catalytic oxidation performance at 120 ℃, and the highest TOF value (70554 h-1) significantly better than AuPd/TiO2-H (39512 h-1) and AuPd/TiO2-E (14814 h-1 ). The reaction kinetics experiment results indicated that the AuPd/TiO2-G has the lowest apparent activation energy (55.77 kJ/mol), which is significantly lower than AuPd/TiO2-H (72.78 kJ/mol) and AuPd/TiO2-E (82.83 kJ/mol). A higher content of oxygen vacancy in the support is conducive to the formation of smaller-sized AuPd nanoparticles and a higher content of surface Pd0 species on the catalyst surface, which is the key to achieving the excellent catalytic activity of AuPd/TiO2-G in the benzyl alcohol catalytic oxidation reaction.