Using hydrothermal synthesis method, the HPW@UiO-66(Ce) composite materials was prepared by loading phosphotungstic acid (HPW) on the cerium-based metal organic framework materials UiO-66(Ce). And then HPW@UiO-66(Ce) was characterized by SEM, XRD, FT-IR, BET, UV-DRS, XPS methods. The photocatalytic degradation performance of HPW@UiO-66(Ce) on tetracycline degradation was evaluated, and the photocatalytic mechanism was discussed. The results showed that the HPW@UiO-66(Ce) composites enhanced the photocatalytic degradation of tetracycline by broaden the visible light absorption range of UiO-66(Ce). The HPW@UiO-66(Ce)-0.7 had the best activity for photocatalytic degradation of TC, and the degradation efficiency of TC at 60 mg/L could reach 96.43% when the material dosage was 0.5 g/L in visible light for 90 min. The hole (h₊^{), superoxide radical (?O_2?}) and hydroxyl radical (.OH) play a major role in the photocatalytic degradation of tetracycline.