Metal-organic frameworks(MOF), as a new type of crystalline porous material, has been widely explored in the fields of catalysis, gas separation, sensing, and drug delivery, and as an important new type of porous material, it has great application value in the field of fine chemicals. The premise of MOF’s application is that it can be prepared on a large scale at low cost. However, the traditional solvothermal synthesis method needs to consume more organic solvents, which has the disadvantages of low output, high energy consumption and difficult waste liquid treatment, and does not meet the requirements of green chemical industry development. Nowadays, the green preparation method of MOF is gradually moving towards solventless, in order to realize the balanced development of economic benefits and environmental benefits of industrial production. In this paper, the solvent-free green synthesis of MOF is the theme, and several strategies, such as steam-assisted synthesis, mechanochemical synthesis, solvent-free direct conversion and accelerated aging synthesis, are successively reviewed from less solvent and green solvent synthesis to trace or even solvent-free synthesis. The advantages and dis- advantages of different methods are evaluated, the necessity of realizing scale-up synthesis is pointed out, and the development prospect of MOF in large-scale commercial applications in the future is prospected.