Using biochitosan quaternary ammonium salt (HACC) as functional monomer, acrylic acid (AA), butyl acrylate (BA), isooctyl acrylate (EHA) as soft monomer, methyl methacrylate (MMA) as hard monomer, and ammonium persulfate (APS) as initiator, semi-continuous seed pre-emulsion method was adopted. The water-proof and oil-proof AKD-HACC-A coating paper was prepared by using the method of surface coating with HACC-A and alkyl ketene dimer (AKD). The effects of emulsifier type, reaction time, initiator dosage, reaction temperature and HACC dosage on the particle size distribution and storage stability of HACC-A were investigated. Based on the characterization of FTIR, SEM and EDS, as well as the tests of water and oil resistance, physical properties, mechanical strength and printing effect of the paper, the influences of the coating amount of HACC-A, the ratio of HACC-A and AKD on the Cobb value of the coated paper and the oil resistance grade of kit were investigated. The results showed that the optimal synthesis process of HACC-A was as follows: OP-10 with a mass fraction of 5% (percentage of the total weight of monomer, the same below) is the emulsifier, the reaction temperature is 70 ℃, the amount of initiator APS is 0.8% (percentage of the total weight of monomer, the same below), and the reaction time is 2 h. Under such conditions, the particle size of HACC-A emulsion prepared is about 200 nm, the distribution is narrow, and the blue light is obvious. Stable storage for a long time (60 d); When the amount of HACC is 5 g and the amount of coating is 6 g/m2, the 60 s Cobb value of the paper after HACC-A coating is 54 g/m2, and the kit oil-proof grade is 6, which meets the food packaging standard. When m(HACC-A)∶m(AKD) = 1∶1, the coating amount is 6 g/m2. After coating the paper, the Cobb value of AKD-HACC-A coated paper 60 s is 30 g/m2, and the kit oil proof grade is 10. It showed good barrier properties to common oils (edible oil and pepper oil at room temperature and 105 ℃), organic solvents (ethanol and acetone) and alkaline solutions (hydrochloric acid and NaOH solution), and its oil proof performance was better than that of PE coated paper (Kit oil proof grade 6) and close to that of fluorinated paper (Kit oil proof grade 11). The active groups of amino and hydroxyl groups on the surface of HACC and good film formation play a key role in improving the performance of oil repellant AKD-HACC-A.