红光发射聚集诱导发光分子在光动力治疗中的应用
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浙江科技学院生物与化学工程学院 浙江省农产品化学与生物加工技术重点实验室

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国家自然科学(22105171),浙江省自然科学(LQ20B020002);


Application of aggregation-induced red emission molecules in photodynamic therapy
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Key Laboratory of Chemical and Biological Processing Technology for Farm Products of Zhejiang Province,School of Biological and Chemical Engineering,Zhejiang University of Science and Technology

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    摘要:

    光敏剂是光动力治疗中的核心,对于提高光动力治疗的效果和减少副作用有着至关重要的作用。然而,传统光敏剂在生物体内易发生聚集,这会导致聚集荧光淬灭(ACQ)效应,使得光敏剂的荧光强度和活性氧生成效率降低。同时,传统光敏剂的光吸收和发射波段也存在局限性。红光发射聚集诱导发光(AIE)光敏剂具有聚集态下活性氧产率高、激发/发射光组织穿透力强、背景干扰小、对正常细胞毒性低甚至无毒等优点,在光动力治疗领域有着广阔的应用前景。综述了基于氰基、苯并噻二唑、氟硼二吡咯等吸电子基团的AIE红光光敏剂分子设计原则和在光动力治疗领域的相关应用,以期为更高效、更安全的红光发射AIE光敏剂的分子设计和应用研究提供参考。

    Abstract:

    Photosensitizers are the core substances in photodynamic therapy, which play a crucial role in improving the effect of photodynamic therapy and reducing side effects. However, traditional photosensitizers are prone to aggregation in vivo, which leads to the ACQ (aggregation-caused quenching) effect, resulting in a decrease in the fluorescence intensity and active oxygen generation efficiency of the photosensitizer. Meanwhile, the light absorption and emission wavelength range of traditional photosensitizers also has limitations. AIE (aggregation-induced emission) red-light emitting photosensitizers with high active oxygen production rate in the aggregated state, strong light tissue penetration ability, small background interference, low or even no toxicity to normal cells, etc. have broad application prospects in the field of photodynamic therapy. This review summarizes the design principles of AIE red-light emitting photosensitizers based on cyano, benzothiadiazole, and dipyrromethene fluoroborate electron-withdrawing groups and their relevant applications in photodynamic therapy, with the aim of providing reference for the more efficient and safer molecular design and application research of red-light emitting AIE photosensitizers.

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雷秀明,孙海亚,路胜利.红光发射聚集诱导发光分子在光动力治疗中的应用[J].精细化工,2025,42(7):

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  • 收稿日期:2024-08-29
  • 最后修改日期:2024-10-15
  • 录用日期:2024-09-30
  • 在线发布日期: 2025-07-10
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