文章摘要
潘远凤.一种多响应性纳米凝胶用于盐酸阿霉素的释放[J].精细化工,2020,37(12):
一种多响应性纳米凝胶用于盐酸阿霉素的释放
A multi-responsive nanogels for delivery of doxorubicin hydrochloride
投稿时间:2020-03-15  修订日期:2020-07-12
DOI:
中文关键词: 甘蔗渣  纳米凝胶  多重响应  DOX  药物释放  功能材料
英文关键词: Sugarcane bagasse  Nanogel  Multi-responsive  DOX  Drug release  functional materials
基金项目:广西石化资源加工及过程强化技术重点实验室主任课题基金(2019Z003)
作者单位E-mail
潘远凤 广西大学化学化工学院 panyf@gxu.edu.cn 
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中文摘要:
      以甘蔗渣为原料,用HNO3/H3PO4-NaNO2混合体系氧化甘蔗渣纤维素得到单羧基纤维素,然后在交联剂胱胺双丙烯酰胺(CBA)存在下,甲基丙烯酸酐修饰的单羧基甘蔗渣纤维素(MAMC-SBC)和N-异丙基丙烯酰胺(NIPAM)在水相中通过原位自由基共聚反应,得到具有氧化还原、pH和热响应性的纳米凝胶。通过FTIR、1H NMR、SEM和高精度粒度分析仪对纳米凝胶的结构进行表征。结果表明,纳米凝胶是粒径分布均一的微球,在溶胀状态下平均粒度为183± 2 nm。盐酸阿霉素(DOX)作为模型药物被有效地装载到纳米凝胶中,药物载药效率高达82.7 %。结果发现,通过还原剂、pH和温度及其它们之间的协同效应可以精准地控制药物的释放。
英文摘要:
      Sugarcane bagasse was used as raw material to prepare monocarboxylic sugarcane bagasse cellulose by HNO3/H3PO4-NaNO2 mixture system; then, in the presence of crosslinking agent cystamine bisacrylamide (CBA), redox, pH and thermal-responsive nanogels were prepared via the in-situ free radical copolymerization of methacrylated monocarboxylic sugarcane bagasse cellulose (MAMC-SBC) and N-isopropylacrylamide (NIPAM) in aqueous phase. The results obtained from FT-IR, 1H NMR, SEM and high precision particle size analyzer show that the nanogels were highly uniform with an average particle size were 183± 2 nm. Adriamycin hydrochloride (DOX) was effectively loaded into the nanogels as a model drug with a drug loading efficiency of up to 82.7 %. The results reveal that it can be controlled the release of drugs precisely by reducing agents, pH and temperature and the synergistic effects.
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