文章摘要
花昌林,张锐.PEG-Gemini型非离子表面活性剂的合成及应用[J].精细化工,2020,37(12):
PEG-Gemini型非离子表面活性剂的合成及应用
Synthesis and application of PEG Gemini non-ionic surfactant
投稿时间:2020-04-29  修订日期:2020-08-20
DOI:
中文关键词: PEG-Gemini型非离子表面活性剂  合成  增溶  溶血
英文关键词: PEG-Gemini nonionic surfactant  Synthesis  Solubilization  Hemolysis
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)
作者单位E-mail
花昌林 江西中医药大学 2648421548@qq.com 
张锐 江西中医药大学 79377375@qq.com 
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中文摘要:
      以1,12-十二醇、油酸、聚乙二醇(300,400,600,800,1000)为原料合成一系列Gemini型非离子表面活性剂,并采用IR,NMR对产物进行了结构确证。为了评估Gemini型非离子表面活性剂作为注射用增溶辅料的有效性,在表面张力、增溶性以及溶血活性等方面与Tween 80进行了比较。结果表明:二-9(8)PEG1000, 二-8(9)-羟基-十八烷酸十二烷基二醇二酯(PODD-1000)的安全有效指数是Tween-80的13倍,更适用于作为注射剂的增溶辅料。
英文摘要:
      Abstract: A series of Gemini nonionic surfactants were synthesized from 1,12-dodecanol, oleic acid and polyethylene glycol (300, 400, 600, 800, 1000). The structure of the product was confirmed by IR and NMR. In order to evaluate the effectiveness of Gemini nonionic surfactants as solubilizing excipients for injection, the surface tension, solubilization and hemolytic activity of Gemini nonionic surfactants were compared with Tween 80. The results show that the safety and effective index of PODD-1000 is 13 times that of Tween-80, which is more suitable for solubilizing excipients of injection.
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