深共融溶剂中合成2-取代苯并噻唑类化合物
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Synthesis 2-disubstituted benzothiazole
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    摘要:

    在由氯化胆碱和乙酰胺组成的深共融溶剂中,以邻氨基苯硫酚和芳香醛为原料,通过环化反应,合成了一系列2-取代苯并噻唑衍生物;当氯化胆碱和乙酰胺的摩尔比为1:2时,0.3 mmol邻氨基苯硫酚与0.3 mmol芳香醛在70 ℃的油浴中反应1 h,即可得到最高98%的产物;该方法无需其它催化剂,反应条件温和、操作简单、底物范围广泛;深共融溶剂循环使用4次后,反应产率仍可以达到90%以上。

    Abstract:

    A series of 2-disubstituted benzothiazole were synthesized via cyclization coupling of o-aminothiophenol and aromatic aldehyde in the deep eutectic solvents (DESs), which was made up of choline chloride and acetamide. The best yield of 98% were achieved through 0.3 mmol of o-aminothiophenol and 0.36 mmol of aromatic aldehyde at 70 ℃ for 1 h in deep eutectic solvent, when the molar ratio of choline chloride and acetamide was 1:2. The DESs method does not need additional catalyst, which has the advantages of mild reaction conditions, simple operations and wide ranges of substrates. In addition, the yield of product can still keep up to 90% after the DESs were reused for 4 cycles in the model reaction.

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谢宗波,姜国芳,陈国庆,张灿,王博,乐长高.深共融溶剂中合成2-取代苯并噻唑类化合物[J].精细化工,2021,38(1):0

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历史
  • 收稿日期:2020-06-15
  • 最后修改日期:2020-09-02
  • 录用日期:2020-09-03
  • 在线发布日期: 2020-11-03
  • 出版日期: