文章摘要
谢宗波,姜国芳,陈国庆,张灿,王博,乐长高.深共融溶剂中合成2-取代苯并噻唑类化合物[J].精细化工,2020,37(12):
深共融溶剂中合成2-取代苯并噻唑类化合物
Synthesis 2-disubstituted benzothiazole
投稿时间:2020-06-15  修订日期:2020-09-02
DOI:
中文关键词: 深共融溶剂  氯化胆碱-乙酰胺  环化偶联  2-取代苯并噻唑
英文关键词: deep eutectic solvent  choline chloride-acetamide  cyclization coupling  2-disubstituted benzothiazole
基金项目:
作者单位E-mail
谢宗波 东华理工大学 zbxie@ecut.edu.cn 
姜国芳 东华理工大学  
陈国庆 东华理工大学  
张灿 东华理工大学  
王博 东华理工大学  
乐长高 东华理工大学  
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中文摘要:
      在由氯化胆碱和乙酰胺组成的深共融溶剂中,以邻氨基苯硫酚和芳香醛为原料,通过环化反应,合成了一系列2-取代苯并噻唑衍生物;当氯化胆碱和乙酰胺的摩尔比为1:2时,0.3 mmol邻氨基苯硫酚与0.3 mmol芳香醛在70 ℃的油浴中反应1 h,即可得到最高98%的产物;该方法无需其它催化剂,反应条件温和、操作简单、底物范围广泛;深共融溶剂循环使用4次后,反应产率仍可以达到90%以上。
英文摘要:
      A series of 2-disubstituted benzothiazole were synthesized via cyclization coupling of o-aminothiophenol and aromatic aldehyde in the deep eutectic solvents (DESs), which was made up of choline chloride and acetamide. The best yield of 98% were achieved through 0.3 mmol of o-aminothiophenol and 0.36 mmol of aromatic aldehyde at 70 ℃ for 1 h in deep eutectic solvent, when the molar ratio of choline chloride and acetamide was 1:2. The DESs method does not need additional catalyst, which has the advantages of mild reaction conditions, simple operations and wide ranges of substrates. In addition, the yield of product can still keep up to 90% after the DESs were reused for 4 cycles in the model reaction.
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