文章摘要
孙苗苗,魏培贺,康纯,刘魏征,郝红.可注射CS/PLLA-SA复合水凝胶的制备及载药性能[J].精细化工,2021,38(2):
可注射CS/PLLA-SA复合水凝胶的制备及载药性能
Preparation and the drug loading properties of injectable CS/PLLA-SA complex hydrogel
投稿时间:2020-07-04  修订日期:2020-10-10
DOI:
中文关键词: PLLA-SA  壳聚糖  可注射水凝胶  布洛芬  医药原料
英文关键词: PLLA-SA  chitosan  injectable hydrogel  ibuprofen  drug materials
基金项目:
作者单位E-mail
孙苗苗 西北大学 1411623243@qq.com 
魏培贺 西北大学  
康纯 西北大学 西安理工大学  
刘魏征 西北大学  
郝红 西北大学 haohong@nwu.edu.cn 
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中文摘要:
      摘要:采用先核后臂法以及丁二酸酐(SA)羧基化修饰合成了末端为羧基的四臂星型聚乳酸(PLLA-SA),将其加入丙酮中得到PLLA-SA纳米分散液。壳聚糖(CS)与分散液通过静电作用自组装形成可注射CS/PLLA-SA复合水凝胶,并采用Zeta电位及激光粒度仪、FTIR和SEM等对PLLA-SA、分散液及水凝胶的组成、结构和性能进行表征与测定。PLLA-SA的最大Zeta电位值为-21.89 mV,分散液的平均粒径约为200 nm。在温度为15 ℃,PLLA-SA质量浓度为5 g/L,布洛芬(IBU)与PLLA-SA质量比为1:2,650 r/min搅拌1 h,550 r/min搅拌5 h的条件下,制备出载IBU的PLLA-SA分散液。将分散液与质量浓度为10 g/L的壳聚糖盐酸盐(CS-HCl)按体积比为7:3混合,快速自组装形成载药CS/PLLA-SA复合水凝胶,包封率和载药量分别达到85.34%和28.46%。体外药物释放结果表明,可注射载药水凝胶对IBU具有明显的缓释作用,30 h内药物的累积释放率可达到95.81%。
英文摘要:
      Abstract: The star-shaped PLLA-SA copolymers with terminal carboxyl groups was synthesized successfully by the "core-first" method, and was dispersed into acetone to obtain PLLA-SA nano-dispersion. Then chitosan (CS) and dispersion were self-assembled via electrostatic action to form injectable CS/PLLA-SA complex hydrogel. The composition, structure and properties of PLLA-SA, PLLA-SA nano-dispersion and CS/PLLA-SA hydrogel were characterized by laser particle size and zeta potential analyzer, FTIR and SEM. The maximum zeta potential value of PLLA-SA was -21.89 mV. The average particle size of the PLLA-SA nano-dispersion was about 200 nm. Ibuprofen(IBU)-PLLA-SA nano-dispersion was prepared at PLLA-SA mass concentration of 5 g/L, the mass ratio between IBU and PLLA-SA of 1:2, stirring speed of 650 r/min for 1 h, then of 550 r/min for 5 h, and temperature of 15 ℃. When IBU-PLLA-SA nano-dispersion was mixed with 10 g/L chitosan hydrochloride (7 : 3 volume ratio), the hydrogel was reversible self-assembly formed,and the loading efficiency and loading content of the hydrogel can reach 85.38% and 28.46%, respectively. The in vitro study of drug release indicated that the injectable CS/PLLA-SA complex hydrogel exhibited a significant sustained-release capability for IBU, and the cumulative release rate of IBU could reach 95.81% within 30 h.
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