3-methacrylamide propyl trimethyl ammonium chloride monomer (MAPTAC) is a kind of cationic quaternary ammonium salt monomer with high reactivity, temperature and pressure resistance and acid and alkali resistance, and salt resistance. The various polymers based on the MAPTAC have good application prospects. Firstly, the research progress of the synthesis method and process optimization of MAPTAC monomer and its polymers were introduced, respectively; Secondly, the typical examples of application research of MAPTAC polymers in daily chemical supplies, petroleum exploration, water treatment, medicine and other fields were listed. Finally, constructive opinions were put forward in developing of the MAPTAC polymer products with high relative molecular weight, serialized relative molecular weight and narrow relative molecular weight distribution, strengthening the research on the relationship between structure and performance and expanding the application fields of MAPTAC polymers.