文章摘要
孙亚光.负载NHC-Pd配合物催化Suzuki偶联反应的研究进展[J].精细化工,2021,38(7):
负载NHC-Pd配合物催化Suzuki偶联反应的研究进展
Progress of Suzuki coupling reaction catalyzed by loaded NHC-Pd complexes
投稿时间:2020-12-29  修订日期:2021-03-14
DOI:
中文关键词: 氮杂环卡宾  钯配合物  Suzuki偶联  多相催化
英文关键词: N-heterocyclic carbene  palladium complex  Suzuki coupling  heterogeneous catalysis
基金项目:国家自然科学基金(21671139)
作者单位E-mail
孙亚光 沈阳化工大学 sunyaguang@syuct.edu.cn 
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中文摘要:
      钯催化的Suzuki偶联反应作为有效的构建碳-碳键的方法,在天然产物、药物全合成和有机合成工业中被广泛应用。而目前广泛应用的含钯均相催化剂尽管反应活性高,但昂贵钯金属盐或配合物不易回收,痕量残留于目标产品或者废液中,导致目标产品重金属污染和环境污染等弊端,极大地增加了该反应的成本和降低了产品的安全性,因此期望以易回收使用、低钯浸出的异相催化剂来实现对该反应的高效绿色催化。氮杂环卡宾钯配合物(NHC-Pd)在催化Suzuki偶联反应中具有反应活性高、稳定好等优点常被用作异相催化剂的催化中心。该文从异相催化剂的载体材料如高分子材料、多孔硅材料、碳基材料、金属-有机框架及磁性纳米粒子等出发,综述了近年来NHC-Pd在异相催化Suzuki偶联反应中的最新研究进展,对于今后该研究方向的开展具有指导意义。
英文摘要:
      As an effective method of constructing carbon-carbon bonds, the Suzuki coupling reaction of palladium catalysis has been widely used in natural products, total pharmaceutical synthesis and organic synthesis industries. The currently widely used palladium-containing homogeneous catalysts have high reaction activity, but expensive palladium metal salts or complexes are not easy to be recycled, and traces remain in the target product or waste liquid, causing heavy metal pollution of the target product and environmental pollution, which greatly increases the cost of the reaction and reduces the safety of the product. Therefore, it is expected that a heterogeneous catalyst that is easy to be recycled and low in palladium leaching can be used to achieve high-efficiency and green catalysis of the reaction.The nitrogen heterocyclic carbene palladium complex (NHC-Pd) has the advantages of high reactivity and good stability in catalyzing the Suzuki coupling reaction, and is often used as the catalytic center of heterogeneous catalysts. Starting from the support materials of heterogeneous catalysts such as polymer materials, porous silicon materials, carbon-based materials, metal-organic frameworks and magnetic nanoparticles, this paper reviews the latest research progress of NHC-PD in heterogeneous catalytic Suzuki coupling reaction in recent year, which has guiding significance for the development of this research direction in the future.
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