文章摘要
龚孟翔,刘宸宇,李经国,柳春玉,王大志,乔卫红.基于静电纺丝制备的聚乙烯醇/高岭土止血膜[J].精细化工,2021,(8):0
基于静电纺丝制备的聚乙烯醇/高岭土止血膜
Polyvinyl alcohol (PVA)/kaolin hemostatic membranes based on electrospin technology
投稿时间:2021-02-06  修订日期:2021-04-03
DOI:
中文关键词: 静电纺丝  聚乙烯醇  高岭土  止血材料  止血性能
英文关键词: electrospin  polyvinyl alcohol  kaolin  hemostatic materials  hemostatic quality
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)
作者单位E-mail
龚孟翔 大连理工大学 Mengxiang_Gong@163.com 
刘宸宇 大连理工大学  
李经国 大连理工大学  
柳春玉 大连理工大学  
王大志 大连理工大学  
乔卫红 大连理工大学 qiaoweihong@dlut.edu.cn 
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中文摘要:
      采用静电纺丝技术将高分子聚合物聚乙烯醇/高岭土的水溶液固化,通过改变高岭土的含量,制得一系列止血膜。通过扫描电镜SEM与EDS图谱,分析纤维化止血膜与材料中高岭土颗粒的形貌和元素分布情况,结果表明,,高岭土能够有效分布于膜纤维中。凝血实验表明,由高岭土含量为2%、质量分数为10%的聚乙烯醇水溶液所制得的止血膜具有最佳的止血效果,其猪血的体外抗凝时间为(254 ± 2) s,止血SD大鼠肝损伤只需(167 ± 9) s,肝损伤失血量最小仅为(0.21 ± 0.05) g。进一步探究PK2止血膜的止血机理,发现其可有效激活内、外源性止血途径,对比空白对照组降低血浆凝固时间的比例分别为7.2%、4.7%,且在8 min左右即能生成较为紧密的凝血块。止血膜的低细胞毒性和低溶血率表明其具有较好的应用前景。
英文摘要:
      Solidified the polyvinyl alcohol water solution with different ratio of kaolin to fabricate hemostatic membranes by electrospinning. The SEM and EDS images showed that kaolin had been distributed on the membranes’ fibers. The hemostatic performance experiments showed that membranes made from10% PVA (mass ratio)/2% kaolin (mass ratio) solution performed best on hemostatic quality. It coagulate pig blood in vitro by 254 ± 2 s, and the blood loss and clotting time on SD rats’ hepatic injury experimentwere 167 ± 9 s and 0.21 ± 0.05 g, respectively. The further study on the hemostatic mechanisms, PK2 showed that it could decrease 7.2% and 4.7% clotting time on the APTT (activated partial thromboplastin time) and PT (prothrombin time) tests comparing with the controls, respectively, and it formed strong blood clots about 8 minutes. Combining with the low cytotoxicity and low hemolysis ration, it could be concluded that the PVA/kaolin electrospun membranes had high prospect on commercial application.
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