Sodium lauryl polyoxypropylene-polyoxyethylene ether sulfate (SLP3E3S) was synthesized from lauryl alcohol by propoxylation, ethoxylation, sulfation and neutralization, and characterized by FTIR, ESI-MS and 1HNMR. The interfacial and application properties of SLP3E3S were tested and compared with those of sodium lauryl sulfate (SDS), sodium laureth sulfate (SLE3S) and sodium lauryl polyoxypropylene ether sulfate (SLP3S). The synergistic effects of polyoxyethylene (PEO) and polypropylene chain (PPO) of extended surfactants were investigated. The results showed that the synergistic effects of PEO and PPO led to SLP3E3S displaying the best low foamability (49 mL), emulsifying power of polar oil (19.4 min) and lime soap dispersing power (55.8 mol/mol) among four surfactants, and the electrolyte tolerance (especially the calcium ion tolerance) of SLP3E3S is as good as that of SLE3S while much better than SDS and SLP3S.