To solve the problem that it is difficult to recycle the metal-organic framework material ZIF-8 in aqueous solution, sodium alginate (SA) was used as the base material, the mixed sol of SA and graphene oxide (GO) was dropped into Ca2+ solution by direct drop addition, crosslinking formed SA/GO gel substrate, and then in-situ growth of ZIF-8 on SA/GO substrate. And SA/GO/ZIF-8 composite adsorbent was prepared to remove tetracycline hydrochloride (TC) from environmental wastewater. XRD, TEM and SEM results showed that ZIF-8 grew uniformly on SA/GO gel substrate, and the calculated load rate of ZIF-8 is as high as 34.21%. When the temperature is 25 ℃, pH=7 and TC concentration is 50 mg/L, the equilibrium adsorption capacity of 30 mg SA/GO/ZIF-8 composite adsorbent for TC can reach 125.37 mg/g. Adsorption kinetics and isotherm results showed that the adsorption process of SA/GO/ZIF-8 on TC was controlled by the chemical active site, and it was a uniform monolayer adsorption at the active site. Furthermore, after 6 cycles of adsorption, the removal rate of TC by SA/GO/ZIF-8 composite adsorbent is still above 85%. The method of easy separation and high loading of ZIFs makes SA/GO/ZIF-8 composite sorbents ideal for antibiotic removal from wastewater.