2-ethylhexyl-3-(4-hydroxy-3-methoxyphenyl)acrylate was synthesized from 4-hydroxy-3-methoxybenzaldehyde and diethyl malonate by Knoevenagel condensation under the catalysis of amion acid in isooctanol. We study the factors such as ratio of feed, and the amount of glycin and reaction time on product yeild. The best reaction condition: Stating from 6.08 g (0.04 mol) 4-hydroxy-3-methoxybenzaldehyde, n(diethyl malonate) /n(4-hydroxy-3-methoxy- benzaldehyde) = 1.4，n(glycin) /n(4-hydroxy-3-methoxybenzaldehyde) = 0.15, n(isooctanol) /n(diethyl malonate) = 12, and reacting for 8h, the yield of 2-ethylhexyl-3-(4-hydroxy-3- methoxyphenyl)acrylate was 75.2%. Its structure was characterized by 1HNMR and IR.