Hydroxypropyl cellulose(HPC) with RAFT agents were used to synthesize a grafted poly(N-isopropylacrylamide) (PNIPAM) hydrogel via reversible addition-fragmentation chain transfer (RAFT) polymerization. The influences of HPC molecular weight, density of RAFT molecule on the HPC chain and the component ratio of HPC over NIPAM, to the properties of hydrogels were investigated. It was found that the hydrogels from RAFT polymerization show the fold, thin wall, porous and super-porous net structure, which led to the improved swelling and deswelling properties; Meanwhile HPC didn’t show the influence on the lower critical solution temperature (LCST) and the sensitivity but improved the hydrogels’ mechanical property by the rigidity of HPC molecule compare to the comb grafted PNIPAM hydrogels and conventional hydrogels, and made an attractive future in applications.