Acetylferrocene was synthesized via Friedel-Crafts acylation with ferrocene and acetyl chloride as raw material, dichloromethane as solvent, zinc oxide as catalyst. And optimal condition was concluded by orthogonal, its yield was 86% under the reaction conditions of molar ratio of ferrocene to acetyl chloride and zinc oxide 1:3:1.2. Ferrocenyl thioacetyl morpholine was synthesized via Willgerodt-Kinder reaction with acetylferrocene, sulfur and morpholine as starting material. The optimal condition was concluded by orthogonal, its yield was 65% under the reaction conditions of molar ratio of acetylferrocene to sulfur and Morpholine 1:3:6, reaction temperature was 128℃, reaction time was 4 hours.The product was characterized by elemental analysis, IR, 1HNMR.