Mesoporous Ni-CaO-ZrO2 nano-composites with different Ni content derived from co-precipitation were tested in CH4-CO2 reforming and characterized by means of N2-adsorption/desorption, X-ray diffraction, Temperature programmed reduction/oxidation. It was found that catalysts with lower Ni contents showed better mesoporous structure, and such framework could enhance the dispersion of Ni particles and avoid their sintering during reaction, which in turn promoted the stability of catalysts. however, activity of the catalyst decreased drastically if the content of Ni was too low. On the other hand, too higher lever of Ni content would cause the collapse of the mesoporous structure, sever sintering and so-caused deactivation were happened during reaction.