The Ipomea pes-caprae (Linn.) Sweet leaves extracts were extracted with different polar solvents by ASE. The antioxidant activity of different extracts were evaluated by DPPH assay. The antioxidant activity of ascorbic acid > ethyl acetate extract > ethanol extract > methanol extract > petroleum ether extracts, its IC50 values were 0.2034 mg/mL, 0.8362 mg / mL, 0.8688 mg/mL, 1.8675 mg/mL and 6.6283 mg/mL. The results showed the Ipomea pes-caprae (Linn.) Sweet leaves extracts had an antioxidant activity, and ethyl acetate extract was highest in all extracts.