The innovation and benefits of five awards and winners of the US Presidential Green Chemistry Challenge(PGCC) Awards Program in 2010 are introduced：①The Dow Chemical Company and BASF Chemical Company were awarded greener synthetic pathways award because of their innovative, environmentally benign production of Propylene Oxide via Hydrogen Peroxide. ②Merck & Co., Inc. and Codexis, Inc. were awarded greener reaction conditions award because of their greener manufacturing of Sitagliptin enabled by an evolved Transaminase.③The Clarke Company was awarded designing greener chemicals award because of NatularTM Larvicide: adapting Spinosad for Next-Generation mosquito control.④LS9, Inc. was awarded small business award because of microbial production of renewable PetroleumTM Fuels and Chemicals.⑤Ph.D. J. C.Liao of University of California, Los Angeles was awarded academic award because of his Recycling Carbon Dioxide to Biosynthesize Higher Alcohols.