The Cu, Ni-containing hydrotalcite-like precursors were synthesized by co-precipitation, and calcined at 500 oC to obtain the Cu-Ni-based catalysts for furfural (FFR) liquid-phase hydrogenation in the present work. And at the same time, their catalytic properties were also compared with the corresponding Cu-based or Ni-based catalysts, and the effects of reduction activation temperature, hydrogenation temperature, H2 pressure, reaction time and catalyst amount on furfural catalytic hydrogenation were further investigated in details. The used catalysts were also characterized by XRD and H2-TPR techniques. The results showed that Cu and Ni species in catalysts possessed synergistic effect on the furfural hydrogenation. Both furfural conversion and furfuryl alchol selectivity over Cu11.2Ni4.7-MgAlO catalyst could reach up to above 90%, and its catalytic activity had no obvious decrease after being reused 6 times.