Synthesis of O-ethoxy Benzoic Acid
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TQ612-1

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    Abstract:

    The preparation process for o-ethoxy benzoic acid, a key intermediate for sildenafil, was improved with methylsalicylate. Sodium salt of methylsalicylate was firstly prepared and treated with ethyl bromide to give methyl o-ethoxybenzoate, which was hydrolyzed to afford o-ethoxy benzoic acid (HPLC purity 99.88%). The overall yield was 89.5% and It has been produced in Chongqing Kangerwei phamaceutical Co. Ltd.

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History
  • Received:September 08,2010
  • Revised:November 13,2010
  • Adopted:November 15,2010
  • Online: January 10,2011
  • Published:
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