Abstract: A concise synthetic route was developed for the key intermediate of hexythiazox—5-(4-chlorophenyl)-4-methylthiazolidin-2-one. The cyclocondensation of carbon disulfide with 1-(4-chlorophenyl)-1-hydroxypropan-2-aminium chloride would proceed in one-step at 130 oC, providing (4R,5R)-5-(4-chlorophenyl)-4- methylthiazolidine-2-thione in 82% yield with 99% purity. Subsequently, the intermediate was oxidized by hydrogen peroxide oxidation, producing (4S,5S)-5-(4-chlorophenyl)-4-methylthiazolidin-2-one in 84% yield with 95%purity. It represents a simple and facile method to access (4S,5S)-5-(4-chlorophenyl)- 4-methylthiazolidin-2-one, which shortens the reaction time and reduces the waste discharge. Thus, it is ecology benigh.