Preferential oxidation of CO is an efficient method to remove the small amount of CO from reformed gas. The catalytic performances of different K/Pt molar ratio catalyst coatings in the preferential oxidation of CO in hydrogen rich stream were studied. The results showed that the optimal K/Pt molar ratio is about 1~1.5. When the K amount exceeded this value, the CO conversion decreased significantly. The increase in inlet O2 concentration from 1% to 1.5% can increase the CO conversion and decrease the CO2 selectivity. In addition, the effects of H2O and CO2 were also investigated. The best catalyst coating exhibited a good H2O and CO2 resistance under the best catalytic reaction temperature. The good stability during a continuous test of 100 h indicates high potential of this catalyst coating in commercial preferential oxidation of CO.