Cyclodextrin polymers were synthesized by polyaddition cross-linking reaction of cyclodextrin and diphenyl methane diisocyanate.Infrared spectroscopy(IR), Scanning electron microscopy(SEM), Elemental analyzer(EA) techniques were used to characterize the cross-linked polymers. The factors affecting the adoption capacity of the cross-linked polymer on phenol were investigated, the dosage of cross-linked polymer and initial phenol concentration.The results indicate that the cross-linked polymers retained the structure of β-cyclodextrin cavity, surface morphology changed from layer to layered crosslinking and molecular formula was (C42H70O35)7.45. Under the condition of wastewater pH 5-7,temperature30 ℃, mechanical stirring 150 r/min,the removal rate of the phenol was up to 98.5% at using amount of 40mg /mL in 40 min contact time, The removal rate of the phenol is still up to 97%, after 6 times repeated usage.