The supramolecular system was obtained using poly(N-isopropylacrylamide) with ferrocene as side groups (poly(NIPAM/FCN)) and ?-CD polymer. The inclusion action was investigated by several techniques, including 1H NMR spectra, cyclic voltammetry, UV-vis spectra and dynamic light scattering measurements. The results showed that ?-CD (or ?-CD polymer) could interact with the reduced ferrocene side groups and hardly affect the oxidized form, and the solution properties could be regulated by redox reaction.