In the presence of phase-transfer catalyst, dodecyl glycidyl ether was synthesized from lauryl alcohol and dichloropropanol. The catalyst type, mole ratios, time and reaction temperature were investigated to optimize the reaction conditions. The optimum reaction condition were obtained as follows: n(lauryl alcohol ):n( dichloropropanol )=1:1.60, at 50 ℃ for 4 h and tetrabutyl ammonium bromide as phase tranfer catalysis, the yield of dodecyl glycidyl ether was 73.2%. The structure of product was characterized by IR and NMR. The yield of dodecyl glycidyl ether was calculated by measure its epoxy value.