The effects of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) fluorocarbon surfactant and sodium dodecyl sulfate (SDS) hydrocarbon surfactant mixing ratio on the solution surface tension, interface tension, spreading properties and foam properties have been investigated to find the best mixing ratio in this paper. The results show that the mixing ratio of OBS/SDS has great influence on the mixed solution properties, the cooperative effect varies with the mixing ratio. Some mixed solution—the surface tension slight increase, but the interface tension are significantly lowered, so the spreading properties are greatly improved—can spread on cyclohexane in comparison with the OBS pure solution which can’t spread on cyclohexane. When the molar ratio is 0.46:1 and the concentration is 6.17×10-3mol/L , the spreading properties are the best, the mixed solution can quickly spread on cyclohexane, and the amount of OBS is significantly reduced by 46%. When the molar ratio is 0.15:1, the synergic effects of interface property and foamability are optimum. The best spreading concentration of mixed solution, which is denoted by the sign cs, also has been studied, it is found that the spreading properties of the mixed solution at cmc are not necessarily the best, the deviation between the cmc and the cs exists, and the gap is determined by surfactants properties and mixing ratio.