Six 2-aryl-substituted imidazoles were prepared from corresponding nitriles, which was reacted with aminoacetaldehyde dimethyl acetal through three steps by one-pot method. From study on the effects of sodium methoxide amount, temperature and time of cyclization reaction, the optimum conditions were investigated that the mole ratio of the amount of sodium methoixde to the starting nitriles was ( 0.08～0.12): 1, the cyclization reaction temperature was 80～90℃ and the cyclization reaction time was 3～8 h. The structures of all products were characterized by melting point, Mass, 1HNMR and elemental analysis.