2,10-Epoxypinane was synthesized by the epoxidation of β-pinene using acetonitrile-water as solvent, ketone as catalyst, hydrogen peroxide as oxidant. The effect of ketone, solvent, mole ratio of hydrogen peroxide to β-pinene , pH, reaction temperature and time on the yield of 2,10-epoxypinane was investigated. The results show that the yield of 2,10-epoxypinane could reach 79.6% and its content was 94.6% under the following reaction conditions: the proper catalyst was acetone, the mole ratio of hydrogen peroxide to β-pinene was 5:1, pH was 10.0 , reaction temperature was 30℃,and the reaction time was 8h. The product was characterized by data of GC, GC-MS spectrum, infrared spectrum and 1H NMR spectrum.