Abstract：Sustained-release antibacterial organic/inorganic composite material was prepared with TEOS，trichlosan and γ-aminopropyl triethoxy silane (KH-550). Low-temperature N2 adsorption, SEM and FTIR methods were employed to investigate the BET specific surface area, particle morphology and functional group on the sample surface, Sustained-release ability of the as-made samples was investigated with dissolving experiment on rotary shaker. Bacteriostasis circle experiments were conducted to assess the dissolving antibacterial performance of the samples. It was revealed by the results that organic/inorganic composite antibacterial material with good sustained-release ability could be successfully prepared, and the sustained-release ability could be improved by coupling agent (KH-550).