Di(2-ethylhexyl) 1,2-cyclohexane dicarboxylate(DEHCH) was synthesized by reaction of HHPA with iso-octanol using active carbon supported methanesulfonic acid as catalyst. The optimal reaction conditions are as follows: n(iso-octano):n(HHPA)= 2.4: 1.0, catalyst (2.1% of mass of HHPA and iso-octano), water entrainer cyclohexane 6 mL, reaction temperature 160 ℃～180 ℃, reaction time 2.5 h. The esterification yield is 99.82%. The catalyst was repeatedly used 4 times and esterification rate was still more than 90%. The product is light yellow transparent oily liquid and the content of DEHCH ranges up to 99.15% by means of HPLC test. The acid value，density，heat weight loss，viscosity and TG curve of product were respectively measured．In conclusion，DEHCH can satisfy the requirements of plasticizer．