The dry stems and leaves of Drypetes hainanensis were extracted with ethnol, then the total extracts were respectively extracted with petroleum ether, ethyl acetate and n-butanol. Whereafter, the antioxidant activities of the total extracts with ethnol and all the other extractions were investigated with DPPH and FRAP assay. The results displayed that the IC50 of extracts of D.hainanensis (DH), extracts of petroleum ether (DHMSO), extracts of ethyl acetate (DHEtOAC), extracts of n-butanol (DHNBA), extracts of water (DHH2O) were 77.3, 115.2, 51.4, 342.9, and 205.7 μg/mL, respectively, with DPPH method, and their FRAP values were 11712.2±931.8, 10820.9±690.5, 14386.4±568.8, 1157.6±63.3, 5584.1±182.3 μmol Fe2+/g, respectively, as well. The IC50 of ascorbic acid (Vc) and BHT are respectively 10.7 and 47.1 μg/mL, and their FRAP values are 18022.8±63.3 and 14568.7±137.0 μmol Fe2+/g, respectively. In addition, multi-cluster showed that DH, DHMSO, DHEtOAC, BHT and Vc had a similar intensity of antioxidant activity, therefore, they could be classified into the same type material. Also, it was found that the antioxidant activity of DHEtOAC could be comparable with BHT, accordingly, the crude extracts had strong antioxidant activity. So in those domains of pharmaceutical, health care, cosmetics and so on forth, D.hainanensis has wide-ranging research and application prospects.