Glutaraldehyde is prepared with cyclopentene as material,tungstic acid as catalyst,tert-butanol as solvent and hydrogen peroxide as oxidation in the microchannel reactor.The effects of the tungstic acid catalyst dosage,reaction temperature,residence time and additives on the experimental are evaluated.Optimal experimental conditions:the molar concentration of tungstic acid catalyst is 0.02mol/L,reaction temperature is 40℃,residence time is 4.5h;When adding KBr,the molar concentration of KBr is 0.02mol/L,residence time is reduced to 2h,conversion rate of cyclopentene is greater than 98%,selectivity is up to 93%.Studies have shown that application of microchannel reactor to improve the selectivity of this reaction is due to the unique structure of the reactor can control the intermediate generation and conversion process.For such a complex reaction of intermediate process,we can get the desired response effect by controlling the residence time to complete the puzzle for ordinary reactor.