Abstract：Sustained-release antibacterial organic/inorganic composite material was prepared with TEOS，trichlosan and γ-aminopropyl triethoxy silane (KH-550), and its thermal stability was investigated. SEM, FTIR and DSC/TG methods were employed to investigate the particle morphology, surface functional group and its thermal stability. Bacteriostasis circle experiments were conducted to assess the dissolving antibacterial performance of the calcined samples. It was revealed by the results that the as-made organic/inorganic composite antibacterial material exhibited good thermal stability. The dissolving antibacterial could be partially preserved even after calcination under 300oC for 30min. The as-made samples were also applied in powder coatings, and coatings with high antibacterial ability were obtained.