4-(sec-butyl)-2,6-di-tert-butylphenol was synthesized from 4-(sec-butyl) phenol and isobutene using sulfuric resin as catalyst. The influence of the catalyst, reaction temperature, reaction time, material ratio and catalyst dosage on the yield of the product had been investigated. The optimal reaction condition was using sulfuric resin as catalyst, choosing the amount of catalyst for 3%~5% (quality ratio), the molar ratio was n(4-(sec-butyl) butylphenol):n(isobutene)=1:2, the reaction temperature 90~100℃, the reaction pressure 0.15 ~0.2Mpa, the reaction time 4 hours. Under the optimal reaction condition, the conversion was more than 90% and selectivity was more than 95%. More than 97.5% of the 4-(sec-butyl)-2,6-di-tert-butylphenol was obtained by distillation separation.