VO(acac)2 was synthesized from V2O3 in the present study. In the synthesis process, three oxidizing agents including air, O2, and H2O2, and toluene as a kind of water entrainment agent were introduced to facilitate the reaction and realize the continuous green synthesis of VO(acac)2. The effects of oxidizing agents were detected and the obtained VO(acac)2 was compared with commercial VO(acac)2. The results show that the yield of VO(acac)2 was significantly promoted and above 80% when used oxidizing agent. O2 was found be the most efficient oxidizing agent. The yield of VO(acac)2 can reach to 90% when O2 flow rate was 200 mL/min and reflux time was 2 h. XRD, FTIR and TG results show that the VO(acac)2 synthesized in this paper has high purity and is comparable to commercial VO(acac)2.