The catalytic process of tetrahydrofurfuryl alcohol(THFA) and ammonia by fixed-bed reactor to give pyridine was studied. Various Ni-NiO content of Ni-NiO/γ-Al2O3 catalysts were prepared. The catalyst was characterized. The catalytic effect of the reaction between tetrahydrofurfuryl alcohol and ammonia to obtain pyridine and other main byproducts was estimated. The influences of temperature, molar ratio of ammonia and THFA， and LHSV on the catalytic reaction were investigated. The catalytic results of Ni-NiO/γ-Al2O3 catalyst were given as the followings. With the increase of Ni-NiO content in catalyst, the content of pyridine and isoquinoine in products increases. Piperidine content decreases; In certain temperature range between 350℃~550℃, with the temperature increasing, pyridine content in products increases. Piperidine content decreases. Isoquinoline content has higher value at the temperature of 400℃.