[2,7,12,18-tetramethyl-3,8-bis(-2-hydroxy ethyl)-13,17-methoxy carb- onyl ethyl]-porphyrin was prepared from hemin by a three-steps reaction including demetalation, esterification, anti-Markovnikov addition. In the synthesis process of protoporphyrin dimethyl ester, environmental friendly ultrasound method was put to use with the yield of 91.6%. [2,7,12,18- tetramethyl-3,8-bis(-2-hydroxy ethyl)-13,17-methoxy carbonyl ethyl]-porphyrin was obtained from the anti-Markovnikov addition of protoporphyrin dimethyl ester with BH3-THF with the yield of 64.3% under reasonably optimized conditions. The target products were characterized with 1HNMR, MS, UV-vis and IR.