Bifonazole as basic remedy was combined with clobetasol propionate and cinnamaldehyde to make a compound. By drafting the pseudoternary phase diagrams, optimal bifonazole nanoemulsion was chosen for quality evaluation. It was found that the mass fraction of optimal bifonazole nanoemulsion was as follows, w (bifonazole) = 1.6%, w (clobetasol propionate) = 0.05%, w (cinnamaldehyde) = 0.15%, w (Tween-80) = 29.5%, w (ethanol) = 9.8%, w (acetic ether) = 13.6%, and w (distilled water) = 45.3%. This oil-in-water nanoemulsion could be easily diluted by water, exhibited a spherical shape without adhesion or aggregation, and presented a Z-average diameter of 10.4 nm and a polydispersity index (PDI) of 0.196. After a 5-fold dilution, the average pH value was 6.1±0.3, and the corresponding zeta potential was (9.18±0.2) mV at 25 ℃. The preparation process of this compound bifonazole nanoemulsion is simple to operate, and the quality can be controlled, standing a chance of potential clinical applications.