Memantine hydrochloride was synthesized from 1, 3-dimethyladamantane through nitration with HNO3 and N-hydroxyphthalimide, hydrogenation under 1MP hydrogen and 10% Pd-C, formation of salt with concentrated HCl. The overall yield reached 80.54%. Optimum condition of nitration was investigated, such as catalyst, quantity of HNO3, reaction time and reaction temperature. Memantine hydrochloride was recrystallized with isopropanol-water and the purity reached 99.87%. Structure of target compound was verified by 1H-NMR and HR-MS.