A new method for the determination of volatile organic compounds (methanol, acetone, methyl acetate, tertiary butanol, vinyl acetate and ethyl acetate) in adhesive for cigarette by headspace gas chromatography was investigated. The effects of temperature programming, equilibrium time, equilibrium temperature and quantity of the adhesive on the experimental result were discussed, and an optimal process variable for the determination of volatile organic compounds was obtained. The results show that the linearity range of this method is 0～400礸 for methyl alcohol, 0～40礸 for acetone, 0～92礸 for methyl acetate, 0～75礸 for tertiary butanol, 0～75礸 for vinyl acetate and 0～45礸 for ethyl acetate, respectively. The relative standard deviations was 0.6%～2.7%, and the recovery was 90.8%～104.2%. This method to determiante volatile organic compounds in adhesive for cigarette is simple, rapid, accurate.