Ethylene glycol monoethyl ether acetate was synthesized from ethylene glycol monoethyl ether and acetic acid with ceric sulfate tetrahydrate as catalyst and cyclohexane as water entrainer. Its structure was confirmed by IR,1HNMR. Effects of molar ratio of ethylene glycol monoethyl ether to acetic acid, the variety and dosage of catalyst , the amount of water entrainer, reaction temperature and reaction time on the yield of the product were studied.Based on 0.2 mole ethylene glycol monoethyl ether,results at acetic acid/ ethylene glycol monoethyl ether molar ratio of 1.5:1, ceric sulfate tetrahydrate / ethylene glycol monoethyl ether mass ratio of 0.05:1,amount of cyclohexane (used as water entrainer) 9 mL, reaction temperature 130℃,for 2 hours reaction time give the highest yield of ethylene glycol monoethyl ether acetate above 97%.