Abstract: The salicylic acid-loaded lecithin/chitosan nanoparticles were prepared by Solvent injection method. The structure, morphology, size distribution as well as surface potential of nanoparticles were investigated. Finally the effects of preparation technology on drug entrapment efficiency by using the dialysis technique were also studied. The preparation process adapted to the formulation was as follows：the concentration of lecithin was 20mg/mL, lecithin-chitosan and SA-carriers weight ratios were 3:1(w/w) and 1:6(w/w) respectively, the pH of Water phase reaches 4. The average diameter of optimized spherical nanoparticles was 150nm with good encapsulation efficiency and drug loading up to 55% and 8.07% respectively, the Zeta potential was 18.7mV. The preparation method of salicylic acid-loaded lecithin/chitosan nanoparticles may provide a new approach for the development of fat-soluble whitening active ingredients-loaded delivery.