Activated carbon was loaded by TiO2 in gel state using sol-gel method, and then calcinated at 500℃ under the protection of nitrogen. TiO2/AC was characterized by BET ，scanning electron microscope (SEM) and XRD. Azithromycin wastewater was treated in a continuous flow photocatalytic reactor with ultraviolet lamp as light source and TiO2 / AC as catalyst. The results show that the azithromycin removal rate of the wastewater was not less than 94.1% under the conditions of load of in TiO2 / AC w(TiO2)=1.24%, pH = 4 and hydraulic retention time 90 min. After 240 hours continuous operation, the azithromycin removal rate differs little.