The purpose of the study was looking for the novel compounds with biological activities. Based on the structure of the compounds with herbicidal activity, according to analogue synthesis, phenyl 3-chloropropanoate was synthesized using phenol and 3-chloropropanoyl chloride as starting materials by condensation reaction. Then 2-(4,6-dimethoxypyrimidin-2-yl)-8-(4,6-dimethoxypyrimidin-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one was synthesized by cyclization reaction, acylation reaction and substitution reaction respectively. The compound was confirmed by 1H NMR, MS and elemental analysis techniques.